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Published Sep 29, 22
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Medical Cannabis Evidence On Efficacy - Dc Health in Chesapeake-Virginia



However, the researchers also noted that studies with larger samples and specific objectives are required before definitive conclusions can be drawn. In contrast, the latest research from 2020 suggests that CBD can help with motor symptoms, specifically tremors. In the Journal of Psychopharmacology, researchers published the results from their study aimed at evaluating the impact of a single dose of 300 mg CBD on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with Parkinson’s disease.

CBD and Parkinson's Disease – Relief for Symptoms? - Fresh Start CBDCannabidiol and Cannabinoid Compounds as Potential Strategies for Treating Parkinson's Disease and l-DOPA-Induced Dyskinesia SpringerLink

In a 2015 study published in Toxicology in Vitro, scientists investigated the potential neurorestorative effects of CBD and the pathways that mediate it for the treatment of Parkinson’s disease. They used rat neurons treated with a neurotoxin that is known to induce Parkinson's disease in vivo and presents with neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced neurotrophic support.

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The data indicated that CBD has neuroprotective effects on neural cells that involves neuritogenesis, NGF receptors as well as an increased expression of axonal and synaptic proteins leading them to conclude that the neuroprotective effects of CBD might be beneficial in Parkinson's disease. The scientific evidence seems to indicate that CBD has the potential to improve quality of life for patients with Parkinson’s disease in addition to reducing neuroinflammation and oxidative stress as well as induce neurogenesis and neuritogenesis that can potentially slow or even reverse disease progression.

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In fact, according to this study, while only 4. 3% of a self-report survey of patients with Parkinson’s disease used cannabis, it ranked among the most effective complimentary and alternative therapies listed. CBD can also play a role as a complementary therapy to help reduce many of the symptoms associated with the pharmaceutical treatments usually prescribed to patients with Parkinson’s disease.

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Likewise, CBD has specifically been shown to help improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder as well as psychosis in Parkinson’s disease patients. The anti-inflammatory, anti-oxidative, neuroprotective and neuroregenaritive effects of CBD can all prove to make it a promising treatment for Parkinson’s disease, for both symptom reduction as well as even potentially slowing down disease progression.

However, it would seem that high dosages of 300 mg/day produced the best effects, probably due to CBD being a pleiotropic drug that produces different effects through multiple molecular pathways at different dosages. As always, speak to your treating physician before using CBD to monitor dosage, symptom severity, and other clinical parameters.

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A number of small studies and anecdotal evidence suggests that cannabidiol (CBD) oil for Parkinson’s may help with some symptoms. However, there is no conclusive research showing CBDs effectiveness in treating Parkinson’s or its symptoms.The Parkinson’s Foundation issued a Consensus Statement on the Use of Medical Cannabis for Parkinson’s Disease in 2020.

The statement urges caution, pointing to potential side effects, and emphasizes the need for more research. That said, as of yet, the Food and Drug Administration has only approved one CBD-based drug for the treatment of a rare seizure disorder. This approval has increased interest in the use of CBD in the treatment of movement disorders, such as Parkinson’s.

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A number of studies suggest that there may be some benefits of CBD for Parkinson’s. The problem is that most of these studies are small, low quality, or animal studies rather than human ones. Additionally, because the FDA does not regulate CBD products, there is no guarantee that product purity is consistent, making it difficult to get the right dose.

More research needs to test this claim. A 2020 study tested Epidiolex, an FDA-approved CBD drug for seizures, for Parkinson’s. Of 13 participants, three quit the study because of side effects. The remaining 10 experienced improvements in their Parkinson’s disease symptoms. However, five of 13 participants developed elevated liver enzymes — a side effect the researchers attribute to the high dose of the drug.

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A 2019 paper reviewed prior studies on CBD and Parkinson’s. The study included four randomized controlled trials. However, just one of these trials showed improvements in Parkinson’s symptoms among participants. In seven preclinical models of Parkinson’s disease, six studies suggested CBD could offer neuroprotective benefits. In three additional trials of CBD and Parkinson’s — one randomized controlled trial, one case series, and one open-label study — participants tolerated CBD well.

Frontiers   Cannabidiol as a Therapeutic Target: Evidence of its  Neuroprotective and Neuromodulatory Function in Parkinson's DiseaseCBD Oil: 9 Science-Backed Benefits – Forbes Health

Non-motor symptoms can be more difficult to treat with standard Parkinson’s treatment. Once again, however, these studies involved only small groups of participants and were short in length. The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.

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